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More recently interest has focused on berberines application for: Weight loss, especially for those with metabolic conditions like type 2 diabetes Blood sugar control Heart health, including cholesterol management Gut health Poly-cystic ovarian syndrome (PCOS) Inflammatory conditions And mood disorders, including mild depression Berberine should be viewed as a complementary supplement rather than a treatment or cure, and it should not replace prescribed medications or professional medical care

( Chen, 2015 ) Histamine is metabolized or cleared from the body via two enzymes, histamine methyltransferase (HNMT) and diamine oxidase (DAO)

It includes positron emission tomography-magnetic resonance (PET MRI) studies of plaque inflammation (plaque 18 F-FDG and 68 Ga-DOTATATE uptake), MRI for plaque morphology and burden, as well as biomarkers, proteomics and RNA profiling, myocardial perfusion reserve and changes in carotid artery total wall volume