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GLP1RAs can inhibit neutral lipid accumulation, ROS generation, and (NADPH oxidase 4) NOX-4 expression in rat cardiomyocytes, thereby migrating interleukin-1 (IL-1 ) induced ROS production [57]

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That means their body mass index (BMI) is at the 95 th percentile or above, increasing their risks of diabetes, heart disease, and other health problems, says Fatima Cody Stanford, MD, MPH, MPA, MBA, an obesity physician-scientist at Massachusetts General Hospital and Harvard Medical School in Boston