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Yes, the combined appetite suppression from both drugs can theoretically create unsafe caloric restriction
2018;11:67-79.[DOI] 150
Some dry mouth can be related to dehydration, which can be dangerous if it's chronic or severe
Because there have been several excellent reviews on changes in choline, creatine and NAA in MS we do not cover the changes in these compounds here other than as relevant to interpreting the glutamate, glutamine and GABA measurements ( In section A Model for Changes in MRS Measured Glutamate, GABA, and Glutamine Levels During the Progression of ALS we present a summary of current theories of how mitochondrial energetics and an altered glutamate/GABA neurotransmitter flux balance play a role in the pathogenesis of ALS
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