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Some participants reported extremely low hunger, lack of interest in food, and difficulty meeting minimum caloric needs

Phase 2 weight loss (48 weeks): 17.1% at 4 mg maintenance 8 mg Weeks 912 Strong therapeutic dose with substantial appetite suppression and metabolic improvements

Results indicate that good oral absorption is more likely with drug molecules that have less than 5 hydrogen bond donors (defined as NH or OH groups)/10 hydrogen bond acceptors (defined as oxygen or nitrogen atoms, including those that are part of hydrogen-bond donors), a molecular weight that is smaller than 500, and a calculated lipophilicity (cLog P) that is smaller than 5 (Lipinski 1995, Lipinski 2000, Lipinski et al