Once the vial is opened or punctured, any bacteria introduced can grow unchecked
Some researchers find that thigh injections produce fewer injection site reactions, while others prefer the abdomen for its reliability
Cyclooxygenase Products: PGE2, PGI2, and TXA2 PGE2, PGI2, and TXA2 are all products of the COX-1 pathway, whereas on the COX-2 side, both PGE2 and PGI2 are produced but TXA2 is NOT: as we'll see this has important effects on thrombogenicity
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Effects in active malignancy are not well characterized, and most clinicians treat this as an exclusion until more data exists