412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1
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If they are used as an adjunct to lifestyle change, where they offer a window to reduce food noise and work on sustainable nutritional, physical and behavioural changes, that weight is far less likely to come back
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There is currently no evidence that FUE is inherently superior to FUT for GLP-1associated presentations