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Signs You May Not Be Getting Enough Benefit If you see no consistent improvement after a short, supervised trial, more frequent isnt automatically the answer
Dose and Formulation The metformin dosage range is between 500 milligrams (mg) and 2,000 mg daily
2 Several factors contribute to this: AEDs such as sodium valproate, carbamazepine, gabapentin, and pregabalin are associated with weight gain Seizure-related fatigue and activity restrictions can reduce physical activity levels Some people with epilepsy experience changes in appetite regulation Obesity itself has been associated with a 2.3-fold increased risk of drug-resistant epilepsy 3 This creates a cycle where AEDs contribute to weight gain, and excess weight may worsen seizure control
This translates to approximately 70+ pounds for someone starting at 250 pounds
During this time, the brain may take time to adjust to a new energy supply, which can temporarily affect focus and mental clarity
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