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The first rate-limiting step in the synthesis of both GSH and hGSH is the formation of -glutamylcysteine (-Glu-Cys) catalyzed by -glutamylcysteine synthetase (-ECS, encoded by GSH1 )

reported significant enrichment of 15 REEs, including Ce, La, and Nd, in tumor tissues compared to adjacent normal tissues, suggesting a possible association with the lung cancer microenvironment, although the biological significance of this finding remains to be further clarified (78)

All experiments were performed in triplicate under low-light conditions to minimize DPPH degradation

[28] Summary of the role of glutathione as a skin-lightening agent While there is no published data for intravenous glutathione, the results of the three randomized controlled trials mentioned above have provided grade Ib and 2b evidence in favour of the skin-lightening effects of topical and oral glutathione, with no significant adverse effects [Table - 1]

The treatment also stimulates collagen production, promoting smoother, more youthful skin