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DOI: 10.1126/science.1360704 31
In the early stages, abnormal NRF2 expression can lead to increased tumor cell proliferation and invasiveness, highlighting the importance of NRF2 in cancer development (57)
However, the study used only two germ cell types (type B spermatogonia and spermatocytes), which made it impossible to evaluate the changes in all cell types during spermatogenesis, and the high concentrations of the drug used in the experiment may have led to exaggerated cytotoxic effects that may not reflect the clinical reality
Lavieu, G
Published in vivo studies have indicated that elevated Ggt1 activity along with cellular glutathione depletion are associated with the increased oxidative stress induced by estrogen deficiency under ovariectomy or menopause conditions (Serviddio et al., 2002
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