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Gastrointestinal (stomach and gut) side effects: the main hurdle Across multiple studies, GI problems are the most common GLP-1 side effects: nausea, vomiting, diarrhoea, and constipation [4]
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Mutations in APP and presenilin genes can increase the A42/A40 ratio, accelerating plaque formation and downstream neurodegeneration, particularly in familial forms of AD [22]
Concomitantly, autophagy was reported to also reduce the hepatocyte apoptosis caused by steatosis and endoplasmic reticulum stress, possibly through the GLP-1RA-stimulated GLP-1R-mediated activation of the EB transcription factor of the autophagy-lysosome pathway, thus reducing the accumulation of liver lipids (201)
Consulting with a healthcare provider is crucial for comprehensively identifying and addressing any underlying causes of fatigue
