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This study identifies up to seven different melanoma cell states and proposes an updated model for melanoma growth, where the stem cell-like population at the top of the hierarchy is dynamic and defined by the microenvironment and niche signals, reconciliating previous conflicting studies disputing dynamic phenotype switching and hierarchical cancer stem cell models for melanoma growth
PBA and TUDCA were furthermore shown to prevent ER stress-induced inhibition of apoB100 secretion, a feature contributing to hepatic steatosis (138) and to ameliorate atherosclerosis in mouse models (139)
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