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Repeated, method-validated measurements (scintigraphy or C-breath testing) in the same participants at treatment start and after weeks of steady state, for cagrilintide monotherapy, to test the tachyphylaxis hypothesis directly

burden in healthy individuals ( M.tb in individuals with T2DM was not previously determined

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The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

CI 0.9 to 0.7%