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Additionally, in RNAi processes, the 5 nucleobase affects the binding activity of AGOs to siRNA, thus reducing target cleavage activity

The brain consumes large am-ounts of oxygen, lacks anti-oxidative compounds, has a high ratio of membrane surface area to cytoplasmic volume, has a high concentration of polyunsaturated fatty uric acids, and contains a large amount of metals.73747576 There have been many evidences suggesting that neuroinflammation and oxidative stress have close interactions and play an important role in the pathophysiology of schizophrenia.777879 Reactive oxygen species (ROS), which include superoxide, nitric oxide, and hydrogen peroxide, are highly reactive molecules, and free radicals are naturally created as byproducts of electron transport and energy metabolism