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While some experimental studies show promising results, this potential benefit remains under investigation
The durability of metabolic benefits after washout, the consequences of chronic pan-ERR activation in heart and kidney, and the potential for tolerance or compensatory network changes require longer studies
In peer-reviewed animal work the concrete numbers are oral doses of roughly 1.442.88 mg/kg given daily to APP/PS1 Alzheimer-model mice over about three months [3] , and low-mg/kg dosing that reversed scopolamine-induced deficits in rodents [1]
106 Because most of the compound is found in the membranes, particularly in the younger tissues (Taylor and coworkers, unpublished data), the concentrations can be orders of magnitude higher
