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The risk of type 2 diabetes mellitus: cardiorenometabolic syndrome and its componentsa call to action

The catabolic path of the carbon skeletons involves simple 1-step aminotransferase reactions that directly produce net quantities of a TCA cycle intermediate

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23-25 Despite those studies showing an overall long-term benefit of tight sugar control in preventing worse retinopathy, a small percentage of subjects had a paradoxical early worsening seen in the first year