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It is contraindicated in patients with certain mitochondrial disorders, porphyria, or fatty acid oxidation deficits
Regarding thyroid and endocrine concerns : rodent studies with GLP-1 receptor agonists have shown C-cell tumours at supratherapeutic doses, but this finding has not been replicated in humans and is not listed as a contraindication in UK or EU SmPCs for approved agents in this class
Semaglutide also improves insulin sensitivity and some cardiometabolic measures, helping reduce HbA1c and triglycerides for people with metabolic disease
Vegetables like broccoli, spinach, kale, cauliflower, and zucchini are vital, as they provide fibre that supports digestion and helps maintain balanced blood sugar levels
Abd El-Kader AM, El-Readi MZ, Ahmed AS, Nafady AM, Wink M, Ibraheim ZZ
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