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The proposed mechanisms include weight loss itself, improved insulin signaling, lower systemic inflammation, and possibly direct effects on GLP-1 receptors expressed by some cancer cells

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Beta cells make insulin and amylin, which help lower blood sugar

Earlier this year, Point32 announced Zepbound would be its preferred GLP-1 drug to treat overweight or obesity in adults, mandating patients switch from other options, such as Wegovy or Saxenda

(B) Semaglutide, as a GLP-1 analog, can directly act on fat cells, increase the expression of thermogenic genes for browning phenotype maintenance, improve the expression of uncoupling protein 1 (UCP1), mitochondrial biosynthesis, and thermogenic marker, or promote fatty browning through nitric oxide synthase (NOS), neuropeptides (NPs), sirtuin 1 (STRT1), signal transducer and activator of transcription 3 (STAT3), and bone morphogenetic protein 4 (BMP4) signaling