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The published PK report documented that co-administration of a single dose of atorvastatin 40 mg with semaglutide 1 mg at steady state increased atorvastatin AUC by 18% and Cmax by 36% [1]
This chemical modification demonstrates the importance of charge distribution in albumin binding, with the anionic character of the -glutamic acid contributing significantly to the overall protein binding affinity
It also slows stomach emptying and reduces the levels of hunger hormones
Combining multiple peptides may increase this risk, potentially leading to allergic reactions or reduced efficacy of either compound
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