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Medication adjustment that was implemented in our study included dose reduction or discontinuation of VPA (6/11), reduction of PHT (2/11) and dose increase in other ASMs (LEV, LCS, OXC) (3/11)
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The fractions containing the complex were pooled and concentrated using an Amicon Ultra concentrator with a 100 kDa cut-off (Millipore) to ~5 mg/ml
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