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The catalytic activity of the molecule was suggested to be, at least partially, involved (since insulin signaling was improved following inclusion of a DPP-4 inhibitor), but the DPP-4 substrate(s) mediating the effect were not identified

Recently, the obvious senescence phenotypes in keloid lesions and fibroblasts were found and senolytic dasatinib was demonstrated to have antifibrotic effects in keloids 14,15

J Biol Chem 286 , 1114111154, doi: 10.1074/jbc.M110.196543 (2011)

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