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The most common adverse effects are gastrointestinal in nature, including nausea, stomach upset, or mild diarrhea
SamirHNyameteasePElbadawyMFathiMMandourASRadwanFet al
Competing interests The authors declare that there is no conflict of interest
Clinical and postmortem studies consistently demonstrate reduced BDNF expression and diminished neurogenic capacity in individuals with depression, while effective antidepressant treatments, including SSRIs, SNRIs, and electroconvulsive therapy, restore neurogenesis and promote neuronal maturation
It is structurally modified from native human IGF-1 through two primary alterations: an arginine substitution at position 3 and the addition of a 13amino acid extension at the N-terminus
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