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Key Research Applications Skin & collagen research: GHK-Cu and BPC-157 together support studies on collagen type I/III upregulation, elastin production, and dermal matrix integrity

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Their secretion of matrix metalloproteinases (MMPs), serine proteases, and cathepsins disrupts the endothelial basement membranes, degrades extracellular matrix components, including collagen, and facilitates the migration of tumor and stromal cells, ultimately promoting tumor angiogenesis and metastasis ( Dixon defined ferroptosis as a unique type of controlled cell death in 2012, based on its iron-dependent mechanism and fundamental deviations from apoptotic pathways ( Figure 3 )