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Retatrutide, because it activates three receptor pathways at once, may cause more gastrointestinal discomfort at higher doses

The proposed mechanism involves preventing GABA receptor downregulation, counteracting compensatory NMDA receptor sensitization, and stabilizing benzodiazepine receptor configuration

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Inhibitors structurally similar to CME can effectively limit the movements of loop regions around the pocket through hydrogen bonds with residues R289 and D180, narrowing the pocket entrance and providing competitive inhibition (Fig