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To assess the importance of lipidation modification to Cagri, pharmacological comparison of Cagri and its non-lipidated backbone (CagriBB) was undertaken using a cAMP response element (CRE)-reporter assay

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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Importantly, the BBB functions as the core of the neurovascular unit (NVU), whose integrity depends on the coordinated homeostasis of surrounding neurons, astrocytes, and the basal lamina