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Body weight affects dosing

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Immunohistochemical staining and western blot assays revealed increased microglial cells and activated astrocytes in the dentate gyrus of the hippocampus in rats with neuropathic pain, along with elevated expression of TNF-, IL-1, and IL-6 [43, 44]

Controlled studies of fermentable fibers like oligofructose and an inulin-propionate ester have shown increases in plasma GLP-1 and PYY alongside improved satiety