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A similar increased response of the PPP was found in the sea cucumber, Apostichopus japonicus , in response to estivation (when feeding stops), suggesting an increased carbon flow into the PPP, as an antioxidant mechanism 77
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IGF-1 is a growth factor, and chronically elevated levels carry theoretical concerns about promoting the growth of pre-existing neoplasms
A patient on trimethoprim-sulfamethoxazole for a urinary tract infection can see serum creatinine jump 0.3 to 0.5 mg/dL within 48 hours
