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Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, Simpson JA, Drucker DJ: GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
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Other 2026 Retatrutide Trials Several other Phase 3 studies have also reported encouraging results: TRIUMPH-4 (Obesity and Knee Osteoarthritis): Results released in December 2025 showed that participants receiving the 12 mg dose lost an average of 28.7% of their body weight after 68 weeks
