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The difference lies in tirzepatides ability to mimic the GLP-1 hormone and the glucose-dependent insulinotropic polypeptide (GIP) hormone

For those who qualify, prescription GLP-1 medications, combined with lifestyle support, offer the most proven approach for achieving significant and sustainable weight loss

[16] Reported rates from trials include: Nausea: ~44% Vomiting: ~25% Diarrhea: ~31% Constipation: ~23% Dyspepsia: ~10% These effects reflect slowed gastric motility and are usually mild, but can lead to clinical implications: Dehydration Electrolyte abnormalities ED presentations for poor oral intake

Stimulants: Cocaine and Amphetamine Research GLP-1 receptor activation has been found to suppress cocaine-stimulated dopamine release