NICE Technology Appraisal guidance (TA875 for semaglutide/Wegovy and TA664 for liraglutide/Saxenda) recommends these medications for weight management in adults with: A body mass index (BMI) of at least 35 kg/m and At least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, or non-alcoholic fatty liver disease) For liraglutide (Saxenda), NICE TA664 specifies additional criteria including prediabetes (HbA1c 42-47 mmol/mol or fasting plasma glucose 5.5-6.9 mmol/L) or high risk of cardiovascular disease
PHASE 1 PHARMACOLOGY First-In-Human Evaluation of LY3437943 Early pharmacokinetic and safety research examining the triple-receptor mechanism that combines GLP-1, GIP, and glucagon receptor activity within a single molecule
Dulaglutide (Trulicity) Once-weekly injection, better tolerated but modest results (35% weight loss)
Interestingly, a retrospective observational cohort study on 18 patients with PTC did identify two patients whose tumor volume increased following exposure to GLP-1RAs (43)
In four months, you could lose up to 40 pounds or more