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The Danish company Novo Nordisk sells several different brand names with semaglutide as an active ingredient: notably, Ozempic, for diabetes and reducing cardiovascular event risks, and Wegovy, for weight loss and reducing cardiovascular event risks
[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered
While generally low risk for healthy individuals, the contamination could lead to serious complications in people with weakened immune systems
Supplementing with mixed forms of natural folate might be a better idea, though studies are lacking to confirm it [ R ]
These medicines are available as injections given daily or weekly, and some (such as Rybelsus) are available as pills
