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siRNA sequences are provided in Supplementary table siRNA section

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[16] Melatonin's concentration in the mitochondrial matrix is significantly higher than that found in the blood plasma, [17] [19] emphasizing its role not only in direct free radical scavenging but also in modulating the expression of antioxidant enzymes and maintaining mitochondrial integrity

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Moreover, the hyperhomocysteinemia associated with an increased cardiovascular risk is stronger in non-insulin-dependent diabetes mellitus than in normal subjects (Hoogeveen et al, 1998)