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Some clinical studies and recent reviews suggest that oral glutathione may contribute to brightening or melasma-related improvement in certain contexts, often around the 250 to 500 mg per day range, but the body of evidence is still relatively small and not as robust as the marketing often implies

Early data showed potentially better body composition outcomes, though more research is needed

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However, as reported concentrations of GSH are in the range of 0.2 mol/l in CSF and 1 mmol/l in brain tissue, 7 GSH in CSF would not appreciably change the MRS determination of GSH in brain tissue

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