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Research suggests that folic acid may benefit the heart and nitric oxide production by increasing DHFR enzyme production, thereby increasing the recycling of BH4.[ref][ref] However, some studies indicate that in people with DHFR variants (see the genotype report), excess folic acid intake may feed back and inhibit DHFR capabilities to increase BH4.[ref] This same DHFR pathway is used for dietary folate, so increasing dietary folate may be another approach to increasing DHFR enzyme production

Dermatology, May 2014, pages 314-325 7

Dyer, K

doi:10.1016/j.ctcp.2015.05.001

Currently, glutathione nasal sprays are in clinical trials at the NIH