semaglutide levothyroxine interaction Interactions with Other Drugs: Safety Guide semaglutide levothyroxine interaction Combined Treatment

10.1038/s41398-021-01571-9 113 XiaoZ.DengQ.ZhouW.ZhangY

doi:10.1056/NEJMoa2307563 60

GLP-1RAs alleviate liver injury by inhibiting hepatocyte apoptosis and promoting the TFEB-dependent transcription of lysosome-related genes, which stimulates hepatocyte autophagy to prevent lipid accumulation (Elsiad et al., 2025

Tirzepatide targets both GLP-1 and GIP receptors (dual action)

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