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GLP-1 (glucagon-like peptide-1) is a hormone naturally produced in the gut that regulates blood sugar and appetite
Until Wegovys MASH indication, patients with F2F3 fibrosis lacked any FDAapproved pharmacologic therapy targeting steatohepatitis resolution and fibrosis improvement, relying primarily on lifestyle modification and bariatric surgery. Against this background, semaglutides ability to deliver sustained doubledigit percentage weight loss, improve cardiometabolic markers, reduce MACE, and favorably modify histologic endpoints in MASH positions Wegovy as a versatile agent across cardiometabolic care pathways, provided its risks and limitations are fully understood and respected
Furthermore, we detected severe outcomes in 46 cases of pancreatic carcinoma and all cases of pancreatic carcinoma metastatic ( n = 12), including 7 and 3 deaths, respectively, consistent with a clinical trial that reported 1 pancreatic carcinoma death, which was assessed as being probably related to semaglutide ( In addition to pancreatitis, among the moderate clinical priority signals, the most commonly reported semaglutide-related AEs were nausea (score 6), vomiting (score 6), diarrhea (score 5), constipation (score 6), and abdominal pain (score 5), and so on, which were consistent with the drug label
PMID: 24723948 Wehr E, Pilz S, Boehm BO, Mrz W, Obermayer-Pietsch B
2018;173:972988.e23
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