One way that insulin resistance affects hormones is by disrupting the function of the hypothalamic-pituitary-adrenal (HPA) axis, which is a complex system that regulates the bodys stress response.In insulin resistance, the body produces more cortisol, a stress hormone that can lead to a range of negative effects, including weight gain, increased appetite, and decreased insulin sensitivity
Clinical trial context: According to the manufacturer, the OASIS 4 trial showed approximately 13-14% average weight loss over 64 weeks, with higher results (up to 16.6%) reported among participants who adhered closely to the treatment protocol
Portincasa, P., Palmieri, V., Doronzo, F., Vendemiale, G., Altomare, E., Sabb, C., Palasciano, G., & Albano, O
Inhibition of the Xc-system determines the decrease in GSH levels, which indirectly leads to the inactivation of GPX4 and the onset of ferroptosis (Ursini and Maiorino, 2020)
They do not give instant energy like caffeine