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Protein J
In high concentrations, homocysteine can increase the risk of heart attacks and strokes since it can damage arterial walls
However, emerging evidence suggests that their benefits extended beyond glycaemic control, with pleiotropic effects on multiple organ systems, including significant anti-fibrotic effects
View Study [3]"Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity" Garvey WT et al., 2025 Finding: The REDEFINE 1 Phase 3 trial showed CagriSema achieved 20.4% weight loss versus 3% with placebo over 68 weeks in 3,417 participants
In a subanalysis of SURPASS-3, tirzepatide 10 and 15 mg resulted also in a relative reduction in liver fat content by 4047% compared to 11% with insulin glargine at 52 weeks [44]
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