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Consistent with the divergent primary sequences, neither the molecular details of degrader engagement (ZZ1 for YPEL5 and thalidomide for CRBN) nor the orientations of the recruited neosubstrates relative to the shared binding groove (Fig

It is responsible for driving fatty acids to the mitochondria where it is used as fuel for energy production

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SR4 significantly suppressed the expression of a number of genes involved in fatty acid and cholesterol synthesis, including acetyl-CoA carboxylase (ACC