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This distinction matters because improvement reflects actual healing rather than masked symptoms

Graham J Burton

The dye cannot pass through viable cell membranes and thus only binds DNA via the compromised membranes of dead cells (Figure 2)

Modifier 59 and CPT 96372: When and How to Use It Modifier 59 signals a "Distinct Procedural Service." Use it with 96372 when a second or subsequent injection is given at the same visit, involving a different drug administered at a different anatomical site

When administered by an experienced and medically trained practitioner the procedure is very safe with complications being extremely rare