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Under normal circumstances, collateral vessels enlarge gradually over weeks to months in response to sustained ischemia

If the solution has precipitated (which can happen if it was frozen or refrigerated improperly), do not inject unless warming the vial to body temperature has fully dissolved the precipitates

Animal Models Used to Stimulate Retinal Artery Occlusion: A Comprehensive Review

The same applies to insulin injections and to the diagnosis and monitoring of treatment of diabetes

Together, they may contribute to fibroblast and immune cell migration by supporting actin filament formation, though these mechanisms remain under investigation