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In addition, prolonged exposure to pharmacologic doses of long-acting GLP-1 RAs induces tachyphylaxis for the effects on gastric emptying, and that is why nausea vanishes quickly after the beginning of treatment in most patients [19]
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Both were 72 week trials in overweight and obese patients with ATTAIN-1 being non-diabetics and ATTAIN-2 being in diabetics
Masters, B
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