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Combination protocols pairing hydroquinone with tretinoin and corticosteroids reduce rebound risk by suppressing the inflammatory MITF upregulation that triggers compensatory pigment production

In vulnerable patients, these interventions can increase serotonin reuptake activity, reducing serotonin availability and worsening depressive symptomsdespite being prescribed with good intentions.

Akbarzadeh, F., Eslamzadeh, M., Behravan, G., Ebrahimi, A., Emami, S

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12 Myth #5: Hormone therapy is dangerous and should only be used in severe cases