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Notwithstanding these limitations, disproportionality analysis still remains a crucial tool for detecting potential safety signals associated with drugs and guiding further investigations [Reference Chen, Ding, Fu and Xiao16, Reference Zhou, Peng, Lin, Jiang, Peng and Gu29, Reference Blau, Tella, Taylor and Rother33, Reference Ding, Chen, Yang, Fang, Cao and Liu52]
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