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Consistent with the effects of GCGR in increasing lipolysis and thermogenesis besides elevating blood glucose levels, preclinical studies have found that peptide 20 improved energy metabolism and hepatic lipid handling without exacerbating preexisting hyperglycemia 22
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Retatrutide, a triple agonist targeting gastric inhibitory polypeptide (GIP), GLP-1, and glucagon receptors, has achieved highly promising outcomes in its phase 2 trial [22], with weight loss up to 24%
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