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We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling

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Thus, the exploration of GLP-1's multifaceted role in health continues to expand, revealing its potential as a key player in not just diabetes and obesity management but also in promoting overall well-being

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