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For visible skin brightening, a series of 612 sessions is usually recommended, with results building over 48 weeks depending on your starting skin tone and treatment frequency

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With fewer sebaceous glands and lower baseline collagen turnover, expect a 30% to 40% improvement in wrinkle depth for mild-to-moderate photodamage over 12 to 16 weeks

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This result could be explained by the fact that catabolism of proline in the gdh3 / gdh3 mutant involves only NAD + -dependent reactions, including the Gdh2- and Put2-catalysed reactions