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Furthermore, vagus nerve-dependent signaling has been shown to mediate peripheral microbial effects on GDNF expression, with stimulation of enteroendocrine cells and immune receptors (TLR2, TLR4) activating downstream PI3K/Akt and MAPK pathways that promote neurotrophic factor production in the CNS
Furthermore, the relative abundance of Akkermansia , a genus positively associated with improvements in obesity-related metabolic issues 60 , was increased in the vehicle-treated group that underwent diet switch relative to the WD control group, suggesting a potential for distinct microbiome-mediated mechanisms of weight loss subsequent to diet switch from those of diet switch in combination with 5A-1MQ treatment
Peterson, James J
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