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While their mechanisms (BDNF upregulation, synaptogenesis) do not directly overlap with monoamine reuptake, the lack of interaction data makes concurrent use inadvisable without baseline and ongoing cardiovascular monitoring
Certain atypical antipsychotics as adjunctive treatment in MDD, such as olanzapine and quetiapine, are also associated with metabolic adverse effects and drug-induced weight gain [150, 151]
Differences in trial duration (6880 wk), populations, dose pooling, DXA timing, estimands, and body-composition calculation methods preclude direct ranking
Additionally, some medications reduce glutathione levels by being substrates for conjugation
You can also report suspected counterfeit medicines to the MHRA through its Yellow Card scheme or FDA through MedWatch
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