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Both the American Diabetes Association and Kidney Disease Improving Global Outcomes organization provide updated pharmacological recommendations for treating T2DM in people with CKD that include the use of sodium-glucose co-transporter-2 inhibitors (SGLT2i) or glucagon-like peptide-1 receptor agonists (GLP-1 RAs)

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Similarly, inhibition of CD38 in aged mice boosted NAD + levels, improving exercise capacity, but in this case, no significant changes in mitochondrial biogenesis-related genes were observed 138

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