The metabolic effects of AKI within the kidney are well-described: disruption of mitochondrial structure, dynamics, biogenesis, and basic electron transport chain function are all present 36
doi:10.1016/j.heares.2023.108786 Pournajaf S, Baerz MM, Khoshsirat S
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One possible explanation is that the anti-inflammatory and neuroimmune effects of GLP-1 receptor activation may occur at lower levels of receptor engagement than the metabolic effects (like weight loss or appetite suppression)